Peer-review articles

Chou A, Torres-Espin A, Kyritsis N, Huie JR, Khatry S, Funk J, Hay J, Lofgreen A, Shah R, McCann C, Pascual LU, Amorim E, Weinstein PR, Manley GT, Dhall SS, Pan JZ, Bresnahan JC, Beattie MS, Whetstone WD, Ferguson AR. Expert-augmented automated machine learning optimizes hemodynamic predictors of spinal cord injury outcome. PLoS One. 2022;17(4):e0265254. doi: 10.1371/journal.pone.0265254. eCollection 2022. PubMed PMID: 35390006; PubMed Central PMCID: PMC8989303.

Agarwal N, Aabedi AA, Torres-Espin A, Chou A, Wozny TA, Mummaneni PV, Burke JF, Ferguson AR, Kyritsis N, Dhall SS, Weinstein PR, Duong-Fernandez X, Pan J, Singh V, Hemmerle DD, Talbott JF, Whetstone WD, Bresnahan JC, Manley GT, Beattie MS, DiGiorgio AM. Decision tree-based machine learning analysis of intraoperative vasopressor use to optimize neurological improvement in acute spinal cord injury. Neurosurg Focus. 2022 Apr;52(4):E9. doi: 10.3171/2022.1.FOCUS21743. PubMed PMID: 35364586.

Miclau TA, Torres-Espin A, Morshed S, Morioka K, Huie JR, El Naga AN, Chou A, Pascual L, Duong-Fernandez X, Kuo YH, Weinstein P, Dhall SS, Bresnahan JC, Beattie MS, Digiorgio A, Ferguson AR. Appendicular Fracture and Polytrauma Correlate with Outcome of Spinal Cord Injury: A Transforming Research and Clinical Knowledge in Spinal Cord Injury Study. J Neurotrauma. 2022 Mar 25;. doi: 10.1089/neu.2021.0375. [Epub ahead of print] PubMed PMID: 35255740.

Torres-Espín A, Haefeli J, Ehsanian R, Torres D, Almeida CA, Huie JR, Chou A, Morozov D, Sanderson N, Dirlikov B, Suen CG, Nielson JL, Kyritsis N, Hemmerle DD, Talbott JF, Manley GT, Dhall SS, Whetstone WD, Bresnahan JC, Beattie MS, McKenna SL, Pan JZ, Ferguson AR. Topological network analysis of patient similarity for precision management of acute blood pressure in spinal cord injury. Elife. 2021 Nov 16;10. doi: 10.7554/eLife.68015. PubMed PMID: 34783309; PubMed Central PMCID: PMC8639149.

Kyritsis N, Torres-Espín A, Schupp PG, Huie JR, Chou A, Duong-Fernandez X, Thomas LH, Tsolinas RE, Hemmerle DD, Pascual LU, Singh V, Pan JZ, Talbott JF, Whetstone WD, Burke JF, DiGiorgio AM, Weinstein PR, Manley GT, Dhall SS, Ferguson AR, Oldham MC, Bresnahan JC, Beattie MS. Diagnostic blood RNA profiles for human acute spinal cord injury. J Exp Med. 2021 Mar 1;218(3). doi: 10.1084/jem.20201795. PubMed PMID: 33512429; PubMed Central PMCID: PMC7852457.

Huie JR, Ferguson AR, Kyritsis N, Pan JZ, Irvine KA, Nielson JL, Schupp PG, Oldham MC, Gensel JC, Lin A, Segal MR, Ratan RR, Bresnahan JC, Beattie MS. Machine intelligence identifies soluble TNFa as a therapeutic target for spinal cord injury. Sci Rep. 2021 Feb 9;11(1):3442. doi: 10.1038/s41598-021-82951-5. PubMed PMID: 33564058; PubMed Central PMCID: PMC7873211.

Torres-Espín A, Chou A, Huie JR, Kyritsis N, Upadhyayula PS, Ferguson AR. Reproducible analysis of disease space via principal components using the novel R package syndRomics. Elife. 2021 Jan 14;10. doi: 10.7554/eLife.61812. PubMed PMID: 33443012; PubMed Central PMCID: PMC7857733.

Mummaneni N, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris M, Pascual LU, Ferguson AR, Russell Huie J, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Weinstein PR, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Cohen-Adad J, Dhall SS, Talbott JF. Injury volume extracted from MRI predicts neurologic outcome in acute spinal cord injury: A prospective TRACK-SCI pilot study. J Clin Neurosci. 2020 Dec;82(Pt B):231-236. doi: 10.1016/j.jocn.2020.11.003. Epub 2020 Nov 25. PubMed PMID: 33248950.

Tsolinas RE, Burke JF, DiGiorgio AM, Thomas LH, Duong-Fernandez X, Harris MH, Yue JK, Winkler EA, Suen CG, Pascual LU, Ferguson AR, Huie JR, Pan JZ, Hemmerle DD, Singh V, Torres-Espin A, Omondi C, Kyritsis N, Haefeli J, Weinstein PR, de Almeida Neto CA, Kuo YH, Taggard D, Talbott JF, Whetstone WD, Manley GT, Bresnahan JC, Beattie MS, Dhall SS. Transforming Research and Clinical Knowledge in Spinal Cord Injury (TRACK-SCI): an overview of initial enrollment and demographics. Neurosurg Focus. 2020 May 1;48(5):E6. doi: 10.3171/2020.2.FOCUS191030. PubMed PMID: 32357323.

Yue JK, Hemmerle DD, Winkler EA, Thomas LH, Fernandez XD, Kyritsis N, Pan JZ, Pascual LU, Singh V, Weinstein PR, Talbott JF, Huie JR, Ferguson AR, Whetstone WD, Manley GT, Beattie MS, Bresnahan JC, Mummaneni PV, Dhall SS. Clinical Implementation of Novel Spinal Cord Perfusion Pressure Protocol in Acute Traumatic Spinal Cord Injury at U.S. Level I Trauma Center: TRACK-SCI Study. World Neurosurg. 2020 Jan;133:e391-e396. doi: 10.1016/j.wneu.2019.09.044. Epub 2019 Sep 14. PubMed PMID: 31526882.

McCoy DB, Dupont SM, Gros C, Cohen-Adad J, Huie RJ, Ferguson A, Duong-Fernandez X, Thomas LH, Singh V, Narvid J, Pascual L, Kyritsis N, Beattie MS, Bresnahan JC, Dhall S, Whetstone W, Talbott JF. Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury. AJNR Am J Neuroradiol. 2019 Apr;40(4):737-744. doi: 10.3174/ajnr.A6020. Epub 2019 Mar 28. PubMed PMID: 30923086; PubMed Central PMCID: PMC7048524.

Kizil C, Kyritsis N, Brand M. Effects of inflammation on stem cells: together they strive?. EMBO Rep. 2015 Apr;16(4):416-26. doi: 10.15252/embr.201439702. Epub 2015 Mar 4. Review. PubMed PMID: 25739812; PubMed Central PMCID: PMC4388609.

Kyritsis N, Kizil C, Brand M. Neuroinflammation and central nervous system regeneration in vertebrates. Trends Cell Biol. 2014 Feb;24(2):128-35. doi: 10.1016/j.tcb.2013.08.004. Epub 2013 Sep 9. Review. PubMed PMID: 24029244.

Kizil C, Kyritsis N, Dudczig S, Kroehne V, Freudenreich D, Kaslin J, Brand M. Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Dev Cell. 2012 Dec 11;23(6):1230-7. doi: 10.1016/j.devcel.2012.10.014. Epub 2012 Nov 15. PubMed PMID: 23168169.

Kyritsis N, Kizil C, Zocher S, Kroehne V, Kaslin J, Freudenreich D, Iltzsche A, Brand M. Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science. 2012 Dec 7;338(6112):1353-6. doi: 10.1126/science.1228773. Epub 2012 Nov 8. PubMed PMID: 23138980.

Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand M. The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Dev. 2012 Jul 23;7:27. doi: 10.1186/1749-8104-7-27. PubMed PMID: 22824261; PubMed Central PMCID: PMC3441421.

Preprints (unpublished)

Fond K, Torres-Espin A, Chou A, Fernandez X, Moncivais S, Huie J, Hemmerle D, Keller A, Singh V, Pascual L, DiGiorgio A, Burke J, Talbott J, Whetstone W, Pan J, Weinstein P, Dhall S, Ferguson A, Bresnahan J, Beattie M, Kyritsis N. Assessing and predicting neuropathic pain after spinal cord injury: a TRACK-SCI study. [preprint]. 2021 December. doi: 10.1101/2021.11.30.21267098.

Datasets

Chou A., Beattie M. S., Bresnahan J. C., Burke J. F., Almeida C. A., Dhall S. S., DiGiorgio A. M., Duong-Fernandez X., Haefeli J., Hemmerle D. D., Huie J., Kyritsis N., Manley G. T., Moncivais S., Omondi C., Pascual L. U., Singh V., Talbott J. F., Thomas L. H., Torres-Espin A., Weinstein P. R., Whetstone W. D., Pan J. Z., Ferguson A. R. (2022) AIS impairment scale, injury characteristics, intraoperative data after spinal cord injury in patients from a TRACK-SCI cohort. Open Data Commons for Spinal Cord Injury. ODC-SCI:727 http://dx.doi.org/10.34945/F5KG6Z

Torres-Espín A., Haefeli J., Ehsanian R., Torres D., Almeida C. A., Huie J., Chou A., Dirlikov B., Suen C. G., Nielson J. L., Kyritsis N., Duong-Fernandez X., Thomas L. H., Hemmerle D. D., Morozov D., Sanderson N., Talbott J. F., Manley G. T., Dhall S. S., Whetstone W. D., Bresnahan J. C., Beattie M. S., McKenna S. L., Pan J. Z., Ferguson A. R. (2021) ASIA Impairment Scale, level of injury, intraoperative time series mean arterial pressure and heart rate after spinal cord injury in patients in a multi-site retrospective TRACK-SCI cohort: site 2 of 2. Open Data Commons for Spinal Cord Injury. ODC-SCI:246 http://dx.doi.org/10.34945/F5MG68

Torres-Espin A., Haefeli J., Ehsanian R., Torres D., Almeida C., Huie J., Chou A., Dirlikov B., Suen C. G., Nielson J. L., Kyritsis N., Duong-Fernandez X., Thomas L. H., Hemmerle D. D., Morozov D., Sanderson N., Talbott J., Manley G. T., Dhall S. S., Whetstone W. D., Bresnahan J. C., Beattie M. S., McKenna S. L., Pan J. Z., Ferguson A. R. (2021) ASIA Impairment Scale, level of injury, intraoperative time series mean arterial pressure and heart rate after spinal cord injury in patients in a multi-site retrospective TRACK-SCI cohort: site 1 of 2. Open Data Commons for Spinal Cord Injury. ODC-SCI:245 http://dx.doi.org/10.34945/F5R59J

Kyritsis N., Torres Espin A., Schupp P. G., Huie J. Russell., Chou A., Duong-Fernandez X., Thomas L. H., Tsolinas R. E., Hemmerle D. D., Pascual L. U., Singh V., Pan J. Z., Talbott J. F., Whetstone W. D., Burke J. F., DiGiorgio A. M., Weinstein P. R., Manley G. T., Dhall S. S., Ferguson A. R., Oldham M. C., Bresnahan J. C., Beattie M. S. (2021) Acute blood RNA sequencing from SCI human patients. Open Data Commons for Spinal Cord Injury. ODC-SCI: 405 http://dx.doi.org/10.34945/F5QC7J